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Plants are already Traditionally a source of analgesic alkaloids, Though their pharmacological characterization is usually constrained. Amongst this kind of purely natural analgesic molecules, conolidine, found in the bark of the tropical flowering shrub Tabernaemontana divaricata, also known as

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Central administration of palmitoylethanolamide lessens hyperalgesia in mice by using inhibition of NF?κB nuclear signalling in dorsal root ganglia. Eur J Pharmacol 1996). Oral PEA also diminished paw oedema induced by carrageenan, dextran and formalin, suggesting which the compound imm

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